In human malignant rhabdoid tumors, loss of SMARCB1 (a subunit of SWI/SNF) leads to Polycomb-mediated repression of genes that suppress proliferation; when SMARCB1 is re-expressed, Polycomb is removed from the chromatin and DNA methylation is lost (Kadoch et al., 2016). This evidence concerns the gene SMARCB1 and rhabdoid tumor.