SMAD4 and neoplasm: Moreover, immunohistochemistry results revealed that tumours from KDC mice treated with 264RAD had significantly reduced proliferation (Ki67), tumour growth signalling (pErk), blood vessel density (endomucin), and TGFβ signalling (nuclear Smad4), and showed a trend towards reduced desmoplasia (reduced αSMA‐expressing myofibroblasts and collagen deposition).