To determine the molecular mechanisms associated with 264RAD‐induced tumour reduction, immunochemistry demonstrated a significant down‐regulation of proliferation (Ki67) and growth signalling (phosphorylated Erk), and a significant up‐regulation of apoptosis (cleaved caspase‐3; Figure 4B) in the 264RAD‐treated tumours compared with control‐treated tumours (p ≤ 0.0001) (Figure 4C). This evidence concerns the gene MKI67 and neoplasm.