SMAD4 and neoplasm: Immunohistochemistry revealed that 264RAD treatment of PDAC‐bearing KDC mice significantly reduced tumour cell proliferation (Ki67), tumour growth signalling (pErk), blood vessel density (endomucin), and TGFβ signalling (nuclear Smad4), and showed a trend towards reduced phosphorylated Smad3, αSMA, and collagen deposition (Figure 5C,D).