This aspect may contribute to its beneficial effect in improving migraine symptomology in some patients, as 5-HT is a potent vasoconstrictor of human cerebral arteries via the 5-HT1Breceptor,37while VEGF is known for its vasodilatory effects.38In addition to warfarin, antiplatelet drugs that also inhibit platelet 5-HT secretion would also be expected to have a similar beneficial antimigraine effect as has been shown in the context of arterial shunt closure with a combination of clopidogrel and ASA.12 The gene discussed is HTR5A; the disease is migraine disorder.