Platelet generation of eicosanoids resulting from the oxidative transformation of arachidonic acid through cyclooxygenase 1 (COX-1) and lipoxygenase (LOX) pathways is an early response to platelet activation.23The development of lipidomics for sensitive and accurate quantitation of a large set of eicosanoids introduces potential new biomarkers of platelet activation, investigated for the first time in AS in our study. The gene discussed is PTGS1; the disease is aortic valve stenosis.