The variability of plasma 12-HETE in our cohort was relatively large, as reported in collagen-stimulated platelets of healthy volunteers before or after aspirin administration.24Although low-dose aspirin has also been reported to affect 12-LOX and to partially reduce 12-HETE production by collagen-stimulated platelets,24the higher levels in patients with AS compared with those with CAD similarly treated by aspirin (Table 2), which remains after adjustment for age, are indicative of in vivo platelet activation induced by the pathological shear stress. Here, ALOX12 is linked to coronary artery disorder.