In addition, our results demonstrate that the overexpression of miR-149-5p can effectively enhance PTX-induced cell apoptosis by inhibiting the expression of MyD88 and by inhibiting the PI3K/Akt signaling pathway, which suggests that this may be an effective strategy for the treatment of PTX resistance to restore the miR-149-5p expression levels in breast cancer cells. This evidence concerns the gene AKT1 and breast cancer.