Generally, ccRCC is a highly vascularized tumor, in which the von Hippel Lindau (VHL) tumor suppressor gene is frequently inactivated, leading to the overexpression of the hypoxia-inducible factor (HIF)-2α oncoprotein and its downstream targets like the vascular endothelial growth factor (VEGF) (3). Here, EPAS1 is linked to neoplasm.