For example, it has been shown that AR may be used as a prognostic marker to promote RCC progression via increased endothelial cell proliferation and altered HIF-2α/VEGF signaling as AR increases endothelial cell proliferation by modulating the AKT- NF-κB- CXCL5 signaling (27). This evidence concerns the gene AKT1 and renal cell carcinoma.