SLC5A2 and diabetes mellitus: With recent large studies confirming cardio and reno-protective properties of SGLT-2 inhibitors [7, 8], and with the new American Diabetes Association (ADA) guidelines [9] and the 2018 American College of Cardiology (ACC) Expert Consensus Decision Pathway [10] recommending consideration of gliflozins as add-on to metformin in a large proportion of diabetics with cardiovascular disease, it is expected that SGLT-2 use will only increase over time.