Because of the known, important roles of basement membrane proteoglycans in invasion (Wight, Kinsella & Qwarnström, 1992; Sanderson, 2001) and the regulation of expression of perlecan under hypoxic condition (Asplund et al., 2010) we hypothesized that perlecan may have expressional changes both in miscarriages and preeclampsia either as a cause or consequence of the common pathology in these syndromes. Here, HSPG2 is linked to Miscarriage.