EIF4E and cancer: In univariate and multivariate (model 1) Cox regression analyses (Table 2), pT1b≤ stage (vs. pT1a), Fuhrman grade 3/4 (vs. grade 1/2), presence of coagulative necrosis (vs. absence), and high eIF4E expression (vs. low) were significantly related to a high risk of recurrence and cancer-specific mortality.