Median TMB of all patients with POLE/D variants was 5 mutations/Mb with no statistically significant difference in POLE/D mutation frequency by etiology: 1/7 (14%) in patients with NASH, 2/96(2%) in patients with HBV including 4 coinfected with HCV and 6/107 (6%) in patients with HCV only. The gene discussed is POLE; the disease is metabolic dysfunction-associated steatohepatitis.