A recent proteomic study showed that phenotypically normal epithelial cells from the colonic crypts of FAP patients, referred to as “one-hit” cells, when compared to normal colon epithelial cells, revealed a significant increase (~27-fold) of the Ethylmalonic encephalopathy protein 1 (ETHE1) which, represented the highest increase in expression among all proteins identified [16]. This evidence concerns the gene ETHE1 and Familial adenomatous polyposis.