Densitometric analysis revealed that upregulation of ETHE1 in HCT116 (Figure 2L) and HT29 (Figure 2M) significantly increased (>2x, p=0.001) expression of COXI, SDBH and NADH. This effect was attenuated by shRNA-mediated silencing of ETHE1 CRC cells, resulting in approximately a 3x to 10x fold reduction (P<0.05) of COXI expression in HT29 and HCT116 (Figure 2L and 2M), respectively. The gene discussed is MT-CO1; the disease is colorectal carcinoma.