ETHE1 and colorectal carcinoma: To study the role of increased ETHE1 levels in CRC, we used human-derived HCT116 and HT29 CRC cell lines that stably constitutively expresses a full-length cDNA encoding ETHE1. Concurrently, gene specific short-hairpin RNA (shRNA) sequences were used to knock-down ETHE1 in these cell lines.