They identified important characteristics of HCC such as significantly mutated genes (e.g. CTNNB1A, TP53, TERT promoter), different promoter methylation profiles (hypermethylation of CDKN2A which causes gene silencing), and key pathways affected in HCC (WNT, SHH, RTK/KRAS, chromatin remodeling and metabolic programming) [3]. The gene discussed is SHH; the disease is hepatocellular carcinoma.