Moreover, some other canonical pathways and hub molecules also get ones to pay more attention to, including iron homeostasis signaling pathway, endoplasmic reticulum stress pathway, inhibition of matrix metalloproteases, mTOR signaling, protein ubiquitination pathway, RAS activation, RhoA signaling, role of tissue factor in cancer, and role of JAK family kinase in IL-6 type cytokine signaling. Here, RHOA is linked to cancer.