In recent years, zonulin, a peripheral marker of TJ and intestinal permeability, has begun to be researched in many areas of medicine including sepsis, autoimmune diseases, malignancy and central nervous system disorders.6 Zonulin levels have been identified to be high in the patient group compared to controls in some studies, while low levels have been identified for some diseases.14-16 Copeptin the stable product of AVP, reflecting the degree of hemodynamic disorder in liver cirrhosis, is a molecule with potential as a prognostic marker. The gene discussed is AVP; the disease is central nervous system disorder.