Patients of RA are now being clinically diagnosed with the help of American College of Rheumatology / European League Against Rheumatism (ACR/EULAR) classification criteria.1 This criterion is based upon four variables i-e small joint involvement, at least 6 months disease duration, positive serology for rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) and presence of any one of the acute phase inflammatory marker i-e Erythrocyte Sedimentation Rate (ESR) or C-Reactive Protein (CRP).1,3. This evidence concerns the gene CRP and rheumatoid arthritis.