The local recurrence rates of breast cancer patients with positive expressions of Ki67 and Topo IIα were 47.2% (25/53) and 50.0% (23/46) respectively, which were significantly higher than those of breast cancer patients with negative expressions (23.1% (3/13) and 25.0% (5/20)). The gene discussed is MKI67; the disease is breast carcinoma.