More importantly, this study found that IGF-1 and ET-1 were in a close correlation with cytokines or bone mineral density in osteoporosis patients, its internal mechanism was generally considered to be correlated to the increased release of inflammatory factors such as IL-18, IL-6 and hs-CR because of the activation effects of IGF-1 and ET-1 on monocyte or macrophage, which further indicated the relationship between the levels of IGF-1 and ET-1 and the condition of osteoporosis patients. Here, EDN1 is linked to osteoporosis.