IGF-1, as a growth factor with high content in bone, plays an important role in regulating osteoclast proliferation and differentiation, osteocyte function, bone metabolism, etc.11 IGF-1 may be closely related to the generating process of osteoporosis.7 ET-1, as a vasoconstrictor peptide, is closely related to the proliferation of vascular endothelial cells. This evidence concerns the gene EDN1 and osteoporosis.