IL1B and periodontitis: Currently accepted theory related to pathogenesis of periodontitis suggests that alteration in host defenses by bacterial and host products stimulates the host inflammatory response, eventually causing tissue damage.5,6 Proinflammatory cytokines are considered to be important modulators of inflammation during the initiation and progression of periodontal disease.7,8 Interleukin (IL)-1, which is a proinflammatory cytokine plays a vital role in immune regulation that causes a variety of inflammatory responses.