Whitaker et al. (2015) have combined findings from genome-wide association studies and analysis of differential gene expression and DNA methylation analysis in RASFs and OASFs. As a result, a number of genes were chosen as prominent candidates for further investigation relevant for RA pathogenesis: ELMO1, LBH, and PTPN11, which are directly involved in the pathogenesis of RA and may be used as therapeutic targets. The gene discussed is LBH; the disease is rheumatoid arthritis.