ITPK1 and systemic lupus erythematosus: Julià et al. (2017) investigated the methylation patterns of B lymphocytes in patients with RA and systemic lupus erythematosus. Differentially methylated in patients and in the control group CpG sites were located in the CD1C, TNFSF10, PARVG, NID1, DHRS12, ITPK1, ACSF3, and TNFRSF13C genes and two intergenic regions (10p12.31). Differential methylation of these genes was also reproduced in the cohort of patients with SLE. This indicates similar patterns of epigenetic changes in B-lymphocytes in these two autoimmune diseases (Julià et al., 2017).