CXCL12 and rheumatoid arthritis: The overexpression of TBX5 affects expression of 790 genes including IL-8, chemokine C-X-C motif ligand 12 (CXCL12) and chemokine C-C motif ligand 20 (CCL20) confirming its role as an inductor and regulator of chemokines important in RA development (Karouzakis et al., 2014).