Despite the great amount of research showing CB1 levels dysregulation centrally in animal models of obesity (South and Huang, 2008; Massa et al., 2010), there is less information about altered hypothalamic Cnr1 mRNA levels, which anyhow have been reported by some (Kempf et al., 2007; Gamelin et al., 2016; Ramirez-Lopez et al., 2016). Here, CNR1 is linked to obesity due to melanocortin 4 receptor deficiency.