In contrast to the findings in breast cancer, Yao et al. have identified palmitoyltransferase ZDHHC3 (DHHC3) as the main acyltransferase required for the palmitoylation of PD-L1 in CRC cells, inhibition of which by 2-bromopalmitate and a synthetic peptide successfully decreases PD-L1 expression and enhances T-cell immunity against the tumors. Here, ZDHHC3 is linked to breast cancer.