Interestingly, some of the down-regulated proteins are known to participate in inflammation (mast cell protease-1, complement C3, T-kininogen 1), adipose tissue metabolism (3-ketoacyl-CoA thiolase B), and oxidative stress (peroxiredoxin-1), or related to steatosis and type 2 diabetes (fetuin-B). Here, C3 is linked to type 2 diabetes mellitus.