ART has been reported to suppress the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis, the expression of osteoclastic-specific genes and the resorption pit formation, as evidenced by rat models of osteolysis and osteoporosis (Zeng et al., 2017; Wei et al., 2018). The gene discussed is TNFSF11; the disease is osteoporosis.