INS and Disorder of lipid metabolism: Previous studies have found that abnormalities in insulin signaling pathways caused by lipid metabolism disorders, inflammatory responses, oxidative stress, endoplasmic reticulum stress, and mitochondrial dysfunction lead to IR (Guilherme et al., 2008; Szendroedi et al., 2011; Gurzov et al., 2014; Park E. et al., 2014; Siwicki et al., 2016).