For instance, SIRT3 overexpression rescues mutant SOD1-induced neuronal cell death (Song et al., 2013), increases neuronal lifespan under mitochondrial oxidative stress (Weir et al., 2012), protects against excitotoxic injury (Kim et al., 2011), mediates adaptive neuronal responses (resistance to oxidative stress, apoptotic cell death) to in vitro bioenergetic, oxidative and excitatory stress (Cheng et al., 2016), and protects mice against noise-induced hearing loss in vivo (Someya et al., 2010). The gene discussed is SIRT3; the disease is hearing loss disorder.