One of the consequences of spinal cord contusion (SCC) has been found to induce the expression of various genes relating to edema and inflammation, including Aquaporin 4 (AQP4) and cytokines (Schwab et al., 1998; Yuan et al., 2000; Schubert et al., 2008), and evidence shows that cellular water entry during cytotoxic edema is mediated by AQP4 channels in astroglial cells in traumatic brain injury (TBI) (Benfenati et al., 2011; Thrane et al., 2011; Hsu et al., 2015; Sturdivant et al., 2016). The gene discussed is AQP4; the disease is spinal cord injury.