By design we have focused on dichotomous measure of inflammation, so we cannot comment on the distributions of continuous CRP values in patients/controls; these have been subject to previous meta-analyses reporting higher mean levels of CRP in depression compared with controls (Howren et al., 2009; Dowlati et al., 2010; Haapakoski et al., 2015; Goldsmith et al., 2016). This evidence concerns the gene CRP and depressive disorder.