F9 and hemophilia B: The partial dysregulation of splicing induced by these neutral variants may not be sufficient to lower the serum FIX levels (to <40%) to induce hemophilia B. Overall, results from our study show that F9 exonic non‐synonymous and neutral variants located outside consensus splice site sequences can induce splicing dysregulation either through activation/creation of cryptic splice sites and/or disruption of SREs.