MYC and lymphoma: The CD2‐MYC model also displays the phenomenon of conditional oncogenesis, as these mice have a low incidence of lymphoma development, and mice that remain healthy display no detectable expression of the transgene.15 Although the CD2 locus control region (LCR) is active from the common lymphoid precursor stage,16 spontaneous tumors in the CD2‐MYC model display productive T‐cell receptor (TCR) rearrangement and express CD3.15 Moreover, analysis of TCR β‐chain usage in CD2‐MYC lymphomas suggests that autoreactive cells may be selected.17