Moreover, the observation that Smyd2 knockout prevents development of MLL‐AF9 leukemia in a mouse model38 reveals an essential role in at least some cancer types, whereas the requirement of MLL leukemias for the RUNX gene activity suggests a functional link to the present findings.61, 62 Although beyond the scope of this study, in future it will be interesting to test the sensitivity of primary RUNX2/MYC lymphomas to the loss of SMYD2 function in vivo. This evidence concerns the gene MLLT3 and lymphoma.