MYC and lymphoma: 18 Moreover, unlike spontaneous tumors in CD2‐MYC mice, CD2‐RUNX2/CD2‐MYC early onset lymphoma cells display a low apoptotic index along with immunoblastic morphology, indicating that this potent oncogene combination overcomes the propensity of RUNX2 and MYC to induce, respectively, growth arrest and apoptosis.18