Moreover, a search among discordantly regulated genes downstream of CD3/TCR and MYC for those potentially coregulated by MYC and RUNX revealed a number of targets with the potential to account for the failure of CD3/MYC‐mediated apoptosis, including Tnfrs8/CD30,54 Interleukin‐1355 and the SOCS family member Cish.56 Although the functional analysis is beyond the scope of this study, it would be of great interest to examine the roles of these targets in lymphoma development in vivo. The gene discussed is CISH; the disease is lymphoma.