HECTD1 and androgen insensitivity syndrome: The possible explanation of these results might be as follows: (a) Increased circRNA HECTD1 expression might promote astrocyte activation via its downstream pathway to increase infract area, resulting in increased disease severity with subsequent higher disease recurrence.7 (b) CircRNA HECTD1 upregulated the level of pro‐inflammatory cytokines and stimulated inflammatory and immune responses, which accelerated disease progression and subsequently increased AIS recurrence.