In the present study, we discovered that: (a) CircRNA HECTD1 expression was increased in AIS patients compared to controls, and ROC curve analysis revealed that circRNA HECTD1 expression was of a good value in distinguishing AIS patients from controls; (b) CircRNA HECTD1 expression was positively associated with NIHSS score and inflammation in AIS patients; and (c) CircRNA HECTD1 expression predicted higher risk of AIS recurrence. Here, HECTD1 is linked to androgen insensitivity syndrome.