Ang‐2 levels progressively increase as the parameters of cardiac function decline in stable chronic heart failure (CHF), and the performance of Ang‐2 in predicting heart failure is similar to that of NT‐proBNP.13 In patients with congenital heart disease, the value of Ang‐2 as a biomarker detecting CHF is comparable to NT‐proBNP.14 However, Ang‐2 cannot predict 1‐year outcome independently of NT‐proBNP in CHF.15 Thus, this study aimed to assess the predictive role of Ang‐2 for the presence of obstructive coronary stenosis as compared with NT‐proBNP in patients with symptoms of CAD. This evidence concerns the gene NPPB and congestive heart failure.