The possible reasons were as follows: (a) Lnc‐THRIL could form a complex with hnRNPL and enhance the transcription of TNF‐α by binding to the promoter region of TNF‐α gene, which induced the increased release of TNF‐α‐related inflammatory cytokine IL‐1β and thereby enhanced the inflammation level of other inflammatory markers in sepsis patients. This evidence concerns the gene HNRNPL and Sepsis.