From the present study, we observed that: (a) 29.4% of sepsis patients developed ARDS during hospitalization, and lnc‐THRIL independently predicted increased risk of ARDS; (b) lnc‐THRIL was positively correlated with disease severity and inflammatory cytokine levels; and (c) lnc‐THRIL was also upregulated in non‐survivors in sepsis patients. The gene discussed is THRIL; the disease is Sepsis.