Univariate logistic regression model analysis exhibited that lnc‐THRIL relative expression (OR = 1.427, P = 0.003), age (OR = 1.041, P = 0.045), smoke (OR = 3.925, P = 0.002), COPD (OR = 4.545, P = 0.006), CRP (OR = 1.006, P = 0.029), and APACHE II score (OR = 1.114, P = 0.007) were correlated with increased risk of ARDS in sepsis patients (Table 2). This evidence concerns the gene THRIL and chronic obstructive pulmonary disease.