PROS1 and brain inflammatory disease: Previous studies in rat and gerbil models of global and focal cerebral ischemia found that protein restriction compromises neurological recovery in motor-coordination tests [5, 7], increases brain inflammation via activation of NF-κb [4], increases neuronal injury [5], and decreases neuronal plasticity, evaluated by the axonal and synaptic proteins growth-associated protein-32, synaptophysin, and synaptosomal-associated protein-25 [6].