We further showed that HNRNPA1 expression increased in cancer and decreased in senescence well explained the related APA-mediated 3′ UTR length changes in HN1. The discovery that HNRNPA1-mediated 3′ UTR length changes in HN1 contributed to cancer- and senescence-associated phenotypes largely expands our knowledge in post-transcriptional regulation in cancer and senescence (Figure 7). Here, JPT1 is linked to cancer.