Importantly, individuals with high HN1 expression tend to have lower survival rates in various cancer types, such as KIRP (Kidney renal papillary cell carcinoma), LIHC (Liver hepatocellular carcinoma), ACC (Adrenocortical carcinoma), HNSC (Head and Neck squamous cell carcinoma), KIRC, PAAD (Pancreatic adenocarcinoma), SKCM (Skin Cutaneous Melanoma), LUAD, and LUSC (Supplementary Figure 5), indicating that HN1 may function in tumor progression. Here, JPT1 is linked to pancreatic adenocarcinoma.