BRAF and melanoma: Finally, when we map the impact of RAC1P29S on transcriptional data from our various in vitro and in vivo model systems against four recently defined, sequential melanoma differentiation states (Tsoi et al., 2018), we see that RAC1P29S induces de-differentiation from a melanocytic toward an undifferentiated state, which has been associated with increased resistance to BRAF inhibitors (Figure 7H).