Because RAC1P29S induces dedifferentiation, it may be that part of its tumor-promoting potential lies in generating more progenitor-like cells from which a tumor can be established, and in making these cells less sensitive to cell death by apoptosis, whether this is induced by a deficient microenvironment or therapy with BRAF inhibitor targeting the main driver oncogene. The gene discussed is BRAF; the disease is neoplasm.