Rates of BRAF and NRAS hotspot mutations were similar in RAC1P29S/L melanomas compared with melanoma in general, while co-occurrence of NF1-inactivating mutations and RAC1P29S/L was significantly enriched in two large melanoma cohorts (cBioPortal cohort, n = 709, log odds ratio 1.73, p < 0.001; GENIE cohort, n = 1,868, log odds ratio 1.71, p < 0.001). The gene discussed is BRAF; the disease is melanoma.