There are insufficient RAC1P29S cases in public clinical datasets to permit robust statistical analyses (e.g., RAC1P29S is present in 2/1,020 and 11/366 cases in the Cancer Cell Line Encyclopedia and The Cancer Genome Atlas [TCGA] melanoma cohort, respectively), so we turned to whole-genome shRNA screening data from human cancer cell lines (Tsherniak et al., 2017), which were used to determine co-dependencies in human cancer cells that require RAC1 for viability. This evidence concerns the gene RAC1 and cancer.