ITCH and neoplasm: For example, circRNA‐000284 is an oncogene and promotes the progression of CC via the miR‐506/Snail‐2 pathway (Ma, Yao, Yu, Chen, & Li, 2018), whereas circ‐ITCH is a tumor suppressor by suppressing the activity of miR‐17/miR‐224 and upregulating their target genes in bladder carcinoma (Yang et al., 2018).