Comparison of our data with a list of EC-related genes obtained from PubMed databases revealed a set of known oncogenic targets (16 genes, Fig. 5d), including tumour suppressor PTEN, whose expression is commonly lost in endometrial cancer tissues [31], the matrix metalloproteinase-2 (MMP2) and YAP1, which are commonly found overexpressed in endometrial cancers [32, 33]. This evidence concerns the gene PTEN and endometrial cancer.