Inhibition of HDAC5 by SAHA in cultured neurons led to the induction of AcH3 and Lxrβ (Fig. 7c–e), and ChIP data showed a significant binding of histone acetylation to the promoters of Lxrβ (Fig. 8), indicating that LXRβ was a downstream target of HDAC5 in ACC of CIP mice. Here, HDAC5 is linked to hereditary sensory and autonomic neuropathy.