NR1H2 and hereditary sensory and autonomic neuropathy: Knockdown of LXRβ expression by lentiviral microinjection into bilateral ACC completely eliminated GW-mediated analgesic effects (p > 0.05, shLXRβ + CFA + GW vs. shNC + CFA group; Fig. 3d, h), whereas lentiviral shLXRα did not affect GW-mediated analgesic effects in CIP mice (p < 0.05, shLXRα + CFA + GW vs. shLXRα + CFA; Fig. 3b, f), suggesting that LXRβ isoform mediated the analgesic effect of GW.