Consistent with our previous data that SNAIL, but not SLUG or TWIST, was expressed in AMD patient samples,35 we found that the Snai1, but not Snai2 or Twist1, mRNA was significantly upregulated in the PRE-choroid complex at 3 days after laser treatment (Figures 3J, S2A, and S2B). This evidence concerns the gene SNAI2 and age-related macular degeneration.