There is thus a need to expand research on the presence and function of CD8+ T cells in peripheral blood from TB patients to better understand the immune response against Mtb, identify the activation pathway needed to eliminate Mtb, optimize strategies for designing new epitopes targeted by mycobacterium‐specific CD8+ T cells, obtain new TB vaccines with better protective immunity than current vaccines, or identify the markers of disease progression. This evidence concerns the gene CD8A and tuberculosis.