CD8A and tuberculosis: Using an in vitro model, it has been demonstrated that LAM has a direct effect on cells, affecting cellular differentiation and functionality.33 It has recently been suggested that the generation of TB vaccines carrying CD8+ T cells stimulates antigens that have the potential to prevent the progression of latent TB infection to TB diseases.34 Thus, our results provide new knowledge regarding the status of CD8+ cells in peripheral blood under Mtb infection.