Our data show that TB patients have a high frequency of CD8+ cells; even if we do not evaluate TCR repertoires, our data are still in agreement with previous reports that described the clonal expansion of CD8+ TCRαβ+ T cells in children and in the macaque model.9, 15 Because CD8+ TCRγδ+ cells were not increased, we assume that the cytotoxic activity of CD8+ TCRαβ+ cells against Mtb could be the most important mechanism in infection control. Here, CD8A is linked to infection.