They are lipoarabinomannan (LAM)‐responsive T cells that contribute to disease outcome.31 By contrast, it has been demonstrated that TB patients have LAM in their peripheral blood.32 We suggest that the high cytotoxic ability shown by CD8+ T cells in TB patients could be a consequence of the frequent interaction of LAM–CD8+ T cells in peripheral blood. This evidence concerns the gene CD8A and tuberculosis.