Analyses of transcripts altered in TMED3 kd cells over control levels revealed a group of 63 RNAs enhanced twofold or more that included several genes previously shown to promote pro-metastatic behavior in different cancers, including SOX8, ASCL2, FGF19, and CXCR4 (Supplemental Fig. 4). The gene discussed is ASCL2; the disease is cancer.