APC and cancer: This may happen in single or small numbers of cells and is consistent with both the wide distribution of βCATENIN, with high levels commonly due to APC mutation, (https://www.proteinatlas.org/ENSG00000168036-CTNNB1/pathology/tissue/colorectal+cancer#img) and the heterogenous expression of high levels of TGFα (https://www.proteinatlas.org/ENSG00000163235-TGFA/pathology/tissue/colorectal+cancer#img) in human colon cancers.