Defining TMED9-regulated genes and searching for factors able to rescue TMED9 kd-induced functional deficiencies allow us to uncover TGFα, a high-affinity ligand for EGFR [69, 76], as a mediator of pro-metastatic TMED9 function: TGFα ligand, rescues the phenotypes of kd of TMED9 and provokes the dispersion of colon cancer epithelial colonies, as in other cancer cells [77]. This evidence concerns the gene EGFR and cancer.