Inspection of regulated genes (Fig. 2c, Supplemental Fig. 3a) revealed potential mechanisms for the anti-metastatic phenotype of kd of TMED9. For instance, genes with enhanced expression included metastatic suppressors (AKAP12), and genes with repressed expression included genes involved in EMT (MMP28, ADAM8, SNAI3) and cancer progression (DPEP1, LAMP3, GSPG4). Here, ADAM8 is linked to cancer.