Top putative pro-metastatic genes listed according to shTMED9/shTMED3 gene expression ratios (Fig. 2e list in red) included FGF19, CLDN2, KCNN4, ADAM8, BGN, PCAT14, and CXCR4, which have been previously linked to pro-migratory, invasive, or metastatic behaviors in different cancers [43–49]. This evidence concerns the gene CXCR4 and cancer.