IL18 and enterocolitis: These now include MR evidence demonstrating important effects of IL18 on IBD risk in the general population, Mendelian gain-of-function mutations leading to increased IL18 levels and severe enterocolitis, which was reversed by IL18 signaling inhibition, cis-eQTLs for IL18 receptors leading to increased IBD risk and finally intestinal biopsies from IBD patients showing increased IL18 expression in epithelial cells.