Among proestrus-specific, Egr1 motif-containing genes, we selected Ncan35 (encoding Neurocan, an extracellular matrix glycoprotein), Gria336 (encoding Glutamate ionotropic receptor AMPA subunit 3), and Ptprt37 (encoding Protein tyrosine phosphatase, receptor type T), since these genes have been implicated in dendritic spine dynamics and long-term potentiation, as well as in mood disorders. The gene discussed is NCAN; the disease is mood disorder.