LAMP5 and Anxiety: To explore candidate genes of relevance to anxiety behaviour and chromatin organization, we selected some of the top genes from the proestrus–dioestrus comparison: Lamp5 (encoding Lysosome-associated membrane protein 5), Dkkl1 (encoding Dickkopf-like acrosomal protein 1), Chd3 (encoding Chromodomain helicase DNA binding protein 3) and Smarcc2 (encoding SWI/SNF related, matrix associated, actin-dependent regulator of chromatin subfamily C member 2), and validated their differential nuclear RNA expression in ventral hippocampal neurons of proestrus and dioestrus females (Fig. 4c).