Compared with normal coronary arteries, NLRC5 expression was more abundant in VSMCs in both Kawasaki disease (Supplementary Fig. 1) and coronary plaques; however, its expression was also ubiquitous, rather than localized in the proliferative medial layer (Fig. 1a–c and Supplementary Fig. 2). This evidence concerns the gene NLRC5 and Kawasaki disease.