Consistent with these findings, in the Broad Institute genome-wide shRNA screening database across 285 cancer cell lines (www.broadinstitute.org/achilles), the top 10 pathways correlated with SETD1A-KD (accounting for 57% of genes analyzed), correspond to cell cycle and mitosis, of which 7 gene sets are significantly associated with sister chromatid cohesion (Fig. 3b, Supplementary Fig. 4a). Here, SETD1A is linked to cancer.