For LMNA, C-to-T conversion (a synonymous mutation, G608G) at the target site would create a cryptic splice donor site that produces a truncated splicing mutant of lamin A/C protein, termed “progerin”, resulting in Hutchinson-Gilford Progeria Syndrome (HGPS)25. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.