FANCD2 and Friedreich ataxia: In the execution of the FA DNA damage response, the E2 ubiquitin conjugating enzyme FANCT (UBE2T) works in conjunction with the E3 ubiquitin ligase FANCL5,6 to monoubiquitinate FANCD2 while the FANCI-FANCD2 (ID2) heterodimer is bound to DNA7–10.