In vitro-derived TH1(+IL-27) populations showed enrichment in blood and lungs from T. gondii, influenza, RSV, B. pseudomallei infected mice; TH2 cells showed dominance in the lungs from HDM allergy challenged mice, but not in blood from HDM allergy challenged mice; and TH17 cells showed a very strong enrichment in the lungs from B. pseudomallei infected mice, with weaker enrichments in C. albicans, influenza infected and HDM-allergen-challenged mice, and in blood of C. albicans infected mice (Fig. 2d). The gene discussed is IL27; the disease is allergic disease.