This dominant module (L26) in HDM allergy, contained increased expression of genes such as Il4, Il5, Il13, and Il33, and the eosinophil-attracting chemokines, Ccl11 and Ccl24, in keeping with the cellular deconvolution analysis (Supplementary Fig. 2b), and genes associated with mast cell function45, in keeping with the significant enrichment for mast cells in this module (Fig. 2a, right panel) (Supplementary Data 2). Here, IL4 is linked to allergic disease.