Strikingly, the upregulation of these type I IFN-inducible genes during infection was totally abrogated in the lungs of the Ifngr−/− and Ifnar−/− × Ifngr−/− mice, demonstrating the dependence of these genes, reported to be induced by type I IFN, on IFN-γ signaling during T. gondii infection (Fig. 6b). The gene discussed is IFNG; the disease is infection.