These findings highlight that certain infections, such as T. gondii and B. pseudomallei, are better preserved between lung and blood than others such as RSV and HDM allergy, and that certain immune responses, such as the IFN response, are better reflected between the lung and blood upon infection, suggesting which immune pathways can become systemic and those which remain local to the insult. The gene discussed is IFNA1; the disease is Allergy.