The single-locus SNP rs4573233, rs710885 and rs785005 SNPs alone had no significant association with colon risk, but when these three SNPs composed a combination with others (rs1902432 and rs2632159), we found that the PCAT1 C G T G T haplotype of rs1902432 – rs4573233 -rs710885 – rs785005 – rs2632159 SNPs significantly decreased the colon risk (OR = 0.75), indicating that the haplotype might be more sensitive than these three single SNP its own, and could also have potential for the prediction of colon cancer risk. This evidence concerns the gene PCAT1 and malignant colon neoplasm.