In the male subgroup, PCAT1 rs2632159 SNP also increased rectal cancer risk by 3.97-fold in the male subgroup (P=0.017, Table 2), while PCAT1 rs710885 polymorphism increased CRC risk by 2.09-fold and colon cancer risk by 2.60-fold (P = 0.033, P = 0.013, Table 2). Here, PCAT1 is linked to malignant colon neoplasm.