The change in plasma RIPK3 from presentation to 48 h (ΔRIPK3) was associated with ARDS in sepsis (OR 1.30, 95% CI 1.03–1.63, per 1⁄2 standard deviation) and trauma (OR 1.79, 95% CI 1.33–2.40). Here, RIPK3 is linked to Sepsis.